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Additionally, the pharmacology on the Lively factors was mainly uncharacterized, and affirmation of SCB use was hindered by an absence of known biomarkers. These information gaps prompted experts throughout multiple disciplines to quickly (1) watch, identify and quantify with chromatography/mass spectrometry the ever-switching contents of herbal incense solutions, (two) figure out the metabolic pathways and key urinary metabolites of a number of usually abused SCBs and (3) discover active metabolites that quite possibly contribute to your significant adverse effect profile of SCBs. This assessment comprehensively describes the emergence of SCB abuse and offers a historical account of the foremost scenario experiences, authorized decisions and scientific discoveries of the "K2/Spice Phenomenon". Hypotheses about probable mechanisms SCB adverse consequences are proposed With this assessment. PubMed Disclaimer Figures Determine 1
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